> Apparently, Xenon does this by acting as an antagonist of the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor, and also by enhancing the effect of ("potentiation of") gamma-aminobutyric acid (GABA). Other drugs that act along the NMDA pathway are Ketamine and Memantine (an Alzheimer's drug). And other drugs that act along the GABA pathway are Benzodiazepines (e.g., Diazepam, Lorazepam-- i.e,. Valium). And apparently Nitrous Oxide (N2O) uses both mechanisms as well. [[Xenon Index]] what might people want to know: - [ ] dosing information - - what do other sources say - [Xenon - Erowid Exp - '80 Xenon 20 Oxygen'](https://erowid.org/experiences/exp.php?ID=102911) - estimates a dose lasting a few minutes was 2-4 liters or 8g of nitrous equivalent based on balloon size - >Emergence from xenon is one and a halftimes faster than from nitrous oxide Dale Pendell - Dale Pendell's book - blood-gas coefficient - pg 274 - load up with oxygen first - [ ] [[Xenon Oxygen Concerns]] how to mix it with oxygen? - alternatively just do it for short enough that no oxygen is ok - can you fill a balloon with oxygen - intake method - [[Xenon Safety]] - also how safe is it clinically - what to expect in terms of feeling - what does the lit say - what we want to discover - dosing - how long it lasts - how long to hold in breath - reports - [Xenon - Erowid Exp - 'Three Sessions Over Three Days'](https://erowid.org/experiences/exp.php?ID=116634) - [Xenon - Erowid Exp - 'Painlessness and Fearlessness'](https://erowid.org/experiences/exp.php?ID=114686) - I feel comfortable saying it obliterates pain and fear. The latter is so interesting. I feel like it could ease death related or even minor health related anxiety in hospital or medical situations. #ch - un ### Xenon Administration Procedure ** During the xenon therapy session, patients were in a lying position, conscious, and maintained verbal contact with the doctor. A face mask was fixed on the patient's face either with a special device or by the patient themselves. The procedure began with denitrogenation (removal of free and dissolved nitrogen from the body) by having the patient breathe pure medical oxygen through a breathing mask for 5 minutes in a semi-open circuit at a gas flow rate of at least 4-6 l/min. Then, the breathing circuit was switched to a closed mode, oxygen supply was stopped, and xenon was introduced into the system at a flow rate of no more than 0.8 l/min. The optimal xenon content in the inhaled mixture was 20-30%. The duration of KseMed inhalation was 10-30 minutes. After this time, the breathing circuit was switched back to semi-open mode, and the patient was given pure oxygen at a gas flow rate of at least 4-6 l/min for 2-5 minutes. Patients were under constant cardiomonitoring during inhalation, with blood pressure recorded before the procedure, at the end of inhalation, and 30 minutes after its completion. Blood oxygen saturation levels were recorded before, during, and after the procedure. The patient's condition was assessed based on subjective feelings. ** - 5m of pure oxygen - blood oxygen saturation - subjective feelings of condition